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The available data on patient-reported outcomes suggest no detrimental effect on quality-of-life (QoL) compared to placebo.

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Red arrow, during the 8 wk of gefitinib treatment, some mice showed light alopecia especially at the region near eyelid.

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Evaluation of gefitinib efficacy according to body surface area in patients with non-small cell lung cancer harboring an EGFR mutation.

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Pearl Cancer Research Network Phase II Trial.

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Although Paclitaxel or Docetaxel, as single agents markedly inhibits the growth of A431, LX-1, SK-LC-16, TSU-PR1, and PC-3, when combined with Gefitinib, partial or complete regression is usually seen.

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For patients with nonsquamous NSCLC who have a response or stable disease after four to six cycles of platinum combination chemotherapy, maintenance chemotherapy with pemetrexed should be considered.

Asian ethnicity and EGF-R mutation positive had more pronounced PFS benefit following maintenance therapy.

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Control mice received similar injections of 200 μg of rat IgG2a isotype control in PBS (BioXcell).

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The FDA granted accelerated approval of alectinib, a TKI that targets ALK and RET, in December, 2015.

United States each year, approximately 60% are gliomas.

Anti-angiogenesis drugs only target one factor, so the other factors continue to stimulate blood vessel growth.

Our finding of 17 mutations in LRP1B further supports the notion that LRP1B genomic alterations are significant in lung cancer pathogenesis ().

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PHARMAC funding of 9-week concurrent trastuzumab (Herceptin) for HER2-positive early breast cancer".

Hypercalcemia: Chronic hypercalcemia may result in vascular calcification and other soft-tissue calcification (IOM, 2011).

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For patients with unknown EGFR status who are unfit for chemotherapy, the phase III TOPICAL study () found a significant survival benefit with first-line erlotinib over placebo but only in those who developed a rash within 28 days.

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After careful consideration of each of these, the expert panel and advisory panel agreed that the primary recommendations of this guideline should focus on EGFR mutation assays and ALK FISH assays.

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Mok et al conducted a large phase III study that compared gefitinib with carboplatin-paclitaxel in the first-line setting in Asian patients who had adenocarcinoma and had never smoked or were former light smokers (none in last 15 years).

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Whilst impressive clinical benefits have been observed for NSCLC with a known driver mutation, acquired resistance is frequently seen and presents us with the next challenge in the goal to deliver unique personalised medicine.

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The efficacy of first-line chemotherapy is associated with KRAS mutation status in patients with advanced non-small cell lung cancer: a meta-analysis.

BNP as a marker of the heart failure in the treatment of imatinib mesylate.

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Characteristics of long-term survivors after treatment for inoperable carcinoma of the lung.

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Drug Resistance Group, Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.

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Evaluation of the LVEF by echocardiography or multiple gated acquisition (MUGA) scanning was performed before the onset of treatment and at the time of the efficacy assessments with the use of the same technique.

Since no standard treatment exists for EGFR-mutated patients who progress while on a reversible EGFR-TKI, strict criteria for definition of acquired resistance have been proposed for better interpretation of clinical trials investigating novel agents in this setting ().

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In their landmark paper, The Hallmarks of Cancer, Hanahan and Weinberg suggest that cancer can be described by a small number of underlying principles, despite the complexities of the disease.

Setting the duration of enrollment to 2 years with a minimum follow-up period of 6 months, we initially planned to enroll 320 patients.

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Equivalent outcome of patients with clinical Stage IIIA non-small-cell lung cancer treated with concurrent chemoradiation compared with induction chemotherapy followed by surgical resection.

Patients were randomly assigned to receive either gefitinib or cisplatin plus docetaxel (administered every 21 days for three to six cycles).

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Radiation therapy uses high-energy x-rays to kill tumor cells.

This work was presented at the 2008 mini-symposium of the AACR; San Diego, CA.

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DPD activity can be evaluated by peripheral blood mononuclear cell radioassay, DPD radioassaygenotyping of DPYD gene by denaturing high performance liquid chromatography (DHPLC), or 2- 13C uracil breath test (UraBT).

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Erlotinib (Tarceva) was approved as a single agent second-line therapy in November 2004.

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In 2015, the FDA approved gefitinib for the first-line treatment of patients with NSCLC whose tumors harbor specific types of EGFR gene mutations, as detected by an FDA-approved test.

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One of the first classes of molecules to be suggested as a potential target for anticancer therapy was the tyrosine kinases (TKs).

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In a phase II study by Timmerman et al, use of SBRT in patients with inoperable NSCLC resulted in a 3-year survival rate of 55.

Koyama contributed equally to this work.

Philadelphia chromosome) in all patients with this disease and can transform hematopoietic cells.

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Vaccination recommendations for workers exposed to sewage or human waste should be developed in consultation with local health authorities.

Furthermore, a cell-penetrating ARF peptide inhibitor of FOXM1 has been shown to selectively induce apoptosis in human hepatocellular carcinoma cell lines and mouse models ().

Dobelbower MC, Russo SM, Raisch KP, Seay LL, Clemons LK, Suter S, Posey J, Bonner JA: Epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib, and concurrent 5-fluorouracil, cisplatin and radiotherapy for patients with esophageal cancer: a phase I study.

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In the second trial, 539 patients with nonsquamous NSCLC with nonprogression after treatment with pemetrexed and cisplatin were randomly assigned to continued pemetrexed or placebo.

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However, at a concentration of 2 μM Gefitinib completely blocks NR6M colony formation.

Clinical Characteristics and Treatment Outcomes of Lung Adenocarcinomas with Discrepant EGFR Mutation Testing Results Derived from PCR-Direct Sequencing and Real-Time PCR-Based Assays.

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Results of a global phase II study with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC).

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Tyrosine phosphorylation: thirty years and counting.

Carmustine (BCNU) and cis -platinum (cisplatin) have been the primary chemotherapeutic agents used against malignant gliomas.

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EGFR inhibitors; however, for all specimens negative with these 2 mutation-specific monoclonal antibodies, that is, most samples overall, molecular testing is still needed.

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ALK FISH has been validated in pathologic specimens but not on cytologic specimens as part of the PROFILE 1005 trial, although the package insert of the Abbott ALK FISH Vysis test kit does not make this fine distinction.

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To determine whether STAT3 phosphorylation had a dose-response relationship with gefitinib resistance in CRC cells, the three CRC cell lines, including HT29, SW480 and C2BBel, were chosen for the experiments.

Tests on mice indicate that imatinib is effective at reducing beta-amyloid in the brain.

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Similarly, patients with EGFR expression and absence of K -ras mutations may be considered for the addition of cetuximab to first-line chemotherapy.

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The finding that overexpression and mutations of EGFR occurred in many types of human cancer make EGFR a promising target for anticancer therapy.

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PREGNANCY and BREAST-FEEDING: Do not become pregnant while taking gefitinib.

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This review has two main objectives.

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In the setting of leptomeningeal disease, which has been historically difficult to treat with conventional chemotherapy, high-dose EGFR TKI has been shown to be clinically tolerable and potentially of some benefit with no dose-limiting toxicity.

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RT-PCR was used to investigate the expression of EGFR and its ligands in both HDS cell lines.

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Toxicity, response and survival data of NSCLC patients participating in a compassionate-use program with gefitinib were reviewed.

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Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction With Physiologically-Based Pharmacokinetic Simulations.

Morphologic Changes in the Bone Marrow in Patients of Chronic Myeloid Leukemia (CML) Treated with ImatinibMesylate.

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Computed tomography-guided core-needle biopsy specimens demonstrate epidermal growth factor receptor mutations in patients with non-small-cell lung cancer.

Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib.

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Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib.

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Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial".

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Radiobiological experiments indicate a possible interaction with gefitinib in some selected cancer cell lines.

Lester JF, MacBeth FR, Coles B: Prophylactic cranial irradiation for preventing brain metastases in patients undergoing radical treatment for non-small-cell lung cancer: a Cochrane Review.

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Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non-small-cell lung cancer: a meta-analysis of survival outcomes.

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Gefitinib reduced tumor load by 89.

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